Pilot platform for the downstream purification of Yeast

Pilot platform for the downstream purification of Yeast

The relevant equipment configuration of Angel Yeast downstream purification pilot platform is as follows:

1. Ceramic membrane filtration system (BNCM3-3-M)

Technical parameter:
Filter accuracy: 50nm
Filter area: 2.5㎡/set
Working temperature: 0-70℃
Working pressure: 0-5bar
Tolerable pH range: 1-14
Maximum withstand pressure: 1MPa
Length of membrane element: 1200±0.2mm
Membrane element filtration area: 0.286 square / branch
Membrane element flow channel size: 19 channels × 4mm
Outer diameter of membrane element: φ30mm±0.1m
Material tank: 200L
Material of wetted parts: SS304
Control method: manual
Power demand: three-phase/380V/50HZ/2.3Kw (it is recommended to reserve power supply according to the factory standard system)
Equipment size: 1400 (length) * 1000 (width) * 2100 (height) mm

Product features and process introduction:
1. Integrated structure design, equipped with rollers, easy to move and use, all inlets and outlets are equipped with quick-install pagoda joints;
2. The main equipment is made of SS304 stainless steel except for the seals;
3. It adopts automatic argon filling protection, single-sided welding, double-sided forming, all welds are polished, smooth and flat, surface finish Ra<1.0µm, fillet welds, external butt welds and pipe ends are smoothly polished, and internal welds Polished and even, the inner and outer surfaces of the pipeline are of high quality, simple operation, clean and hygienic, safe and reliable, and the equipment support is wire-drawn.

Optional membrane element model:
Ceramic microfiltration membrane elements: 50nm, 100nm, 200nm, 400nm, 600nm, 800nm, 1um, 1.2um, 1.5um, 2um
Ceramic ultrafiltration membrane elements: 30nm (200KD), 20nm (150KD), 12nm (100KD), 10nm (20KD), 5nm (8000D), 3nm (2000D)

Basic configuration:
One circulating pump, one material tank, two pressure gauges, two flow meters, one thermometer, three membrane modules, nine membrane elements, one tube heat exchanger, one set of backflushing system, and a basic electrical control cabinet One set, equipment supports, pipes, valves and connecting pipes.

2. Column chromatography system (BNCC400-2-M)

Technical parameter:
Cylinder pressure: ≤0.3MPa
Column volume: 150L/support
Column specifications: Ø400*1400
Cylinder material: polypropylene, acid and alkali and solvent resistance
Peristaltic pump: 0-12LPM, adjustable speed, timing, external control
Bracket material: carbon steel
Equipment size: 2400 (length) * 1000 (width) * 2800 (height) mm

Product features and process introduction:
1. The main components of the system are tank, peristaltic pump and chromatography column. The integrated design of peristaltic pump and chromatography column is set on the same platform for easy use;
2. The inner wall thickness of the tank is 3mm, the inner wall polishing accuracy is Ra0.4, and the external wire drawing/polishing. The tank is equipped with quick-opening normal pressure manhole, rotating CIP cleaning ball, glass tube level gauge, splash-proof respirator, and low-speed paddle agitator;
3. The two chromatography columns are equipped with a peristaltic pump, pressure gauge, and flow meter respectively. Each chromatography column can be used alone, or in parallel or in series at the same time;
4. All the chromatography columns are made of PP, which is resistant to hydrochloric acid corrosion;
5. The peristaltic pump is suitable for low-pressure and large-flow liquid transportation, high efficiency, low vibration, and maintenance-free. It has a 4-digit LET digital display and a timing function: the running time of 0.1S-99h can be set, and the timer will stop automatically when the timer ends. .
6. The peristaltic pump has auxiliary functions such as speed adjustment, direction adjustment, power-down memory, and external control communication. The pump head is made of PPS, which is resistant to corrosive liquids such as organic solvents and acids and alkalis.

Basic configuration:
Two PP chromatography columns, two peristaltic pumps, two pressure gauges, two flow meters, two mixing tanks (jacket), one mixing tank (alkali tank), one mixing tank (acid tank), and two sets of valves , A set of brackets and a set of pipe fittings.

3. Ultrafiltration membrane filtration system (BNUF801-1-M)

Technical parameter:
Working pressure: 0-8bar
Working temperature: 4-55℃
Effective filtration area: ≥25m2
Total installed power: 5.6Kw
Electricity demand: three-phase/380V/50HZ/5.6Kw (it is recommended to reserve power supply according to the factory standard system)
Ultrafiltration membrane core: roll structure, size: 8’×40’
Membrane core material: polyethersulfone composite membrane
Membrane core withstand pH: 2-11
Equipment material: SS304
Equipment size: 2900 (length) * 1000 (width) * 2400 (height) mm
Cleaning water: demineralized water/purified water, recommendations: SiO2≤10ppm, Mn≤0.02ppm, Fe≤0.05ppm, pH=6-8, Ca hardness ≤50ppm
Cleaning cycle: cleaning at the end of each batch of production, membrane cleaning time <2 hours

Product features and process introduction:
1. The integrated skid-mounted structure provides all import and export forms and sizes. The main equipment is made of SS304 stainless steel except for the seals;
2. The system is equipped with a multi-stage vertical centrifugal pump with a circulating pump, and the filter components are made of SS304; the booster pump is started by frequency conversion;
3. The system is manually controlled, and the pressure and temperature are displayed in real time, feedback and alarm protection. When the membrane inlet pressure is higher than the set value (parameters can be set and adjusted, such as ultrafiltration 0.7MPa, nanofiltration 2.5MPa), the pump is protected and automatically shuts down and alarms.
4. The system is equipped with a heat exchanger, and the temperature of the material can be controlled through an external refrigerant;
5. The ultrafiltration system uses an 8-inch membrane core with a filtration area of ​​25m², which is mainly used for separation and purification of material and liquid to remove macromolecular impurities, with fast filtration speed and high production efficiency;
6. It adopts automatic argon filling protection, single-sided welding, double-sided forming, all welds are polished, smooth and flat, surface finish Ra<1.0µm, fillet welds, external butt welds and pipe ends are smoothly polished, and internal welds It is smoothly polished, the inner and outer surfaces of the pipeline are of good quality, simple operation, clean and hygienic, safe and reliable. Wire drawing of equipment support.

Optional membrane element model:
Microfiltration membrane elements: 0.05um, 0.1um, 0.2um, 0.3um, 0.45um
Ultrafiltration membrane elements: 1000D, 2000D, 3000D, 5000D, 8000D, 10KD, 20KD, 30KD, 50KD, 70KD, 100KD, 300KD, 500KD, 800KD
Nanofiltration membrane elements: 100D, 150D, 200D, 300D, 500D, 600D, 800D
Reverse osmosis membrane elements: RO1, RO2, RO3, RO4, RO5, RO6, RO7, SW30, BW30

Basic configuration:
One circulating pump, one jacketed circulating tank, one membrane shell, one membrane core, two flow meters, three pressure gauges, one thermometer, one heat exchanger, one safety filter, one basic electrical control cabinet Sets, one set of frequency conversion control system, equipment brackets, manual valves and several connecting pipes.

4. Nanofiltration membrane filtration system (BNNF801-1-M)

Technical parameter:
Working pressure: 0-25bar
Working temperature: 4-55℃
Effective filtration area: ≥25m2
Total installed power: 18Kw
Electricity demand: three-phase/380V/50HZ/18Kw (it is recommended to reserve power supply according to the factory standard system)
Nanofiltration membrane core: roll structure, size: 8’×40’
Film core material: polyamide composite film
Membrane core withstand pH: 2-11
Equipment material: SS304
Equipment size: 2900 (length) * 1000 (width) * 2400 (height) mm
Cleaning water: demineralized water/purified water, recommendations: SiO2≤10ppm, Mn≤0.02ppm, Fe≤0.05ppm, pH=6-8, Ca hardness ≤50ppm
Cleaning cycle: cleaning at the end of each batch of production, membrane cleaning time <2 hours

Product features and process introduction:
1. The integrated skid-mounted structure provides all import and export forms and sizes. The main equipment is made of SS304 stainless steel except for the seals;
2. The system is equipped with a multi-stage vertical centrifugal pump with a circulating pump, and the filter components are made of SS304; the booster pump is started by frequency conversion;
3. The system is manually controlled, and the pressure and temperature are displayed in real time, feedback and alarm protection. The system is equipped with an automatic protection device. When the membrane inlet pressure is higher than the set value (parameters can be set and adjusted, such as ultrafiltration 0.7MPa, nanofiltration 2.5MPa), the pump will automatically stop and alarm when protected;
4. The system is equipped with a heat exchanger, and the temperature of the material can be controlled through an external refrigerant;
5. The system adopts an 8-inch membrane element with a filtration area of ​​25m², which is mainly used for the rapid concentration of the material liquid at the initial stage, and the filtration speed is fast, which can significantly improve the production efficiency and reduce the concentration time of nanofiltration;
6. Use automatic argon protection, single-sided welding, double-sided forming, all welds are polished, smooth, surface finish Ra<1.0µm, fillet welds, external butt welds and pipe ends are smoothly polished, and internal welds It is smoothly polished, the inner and outer surfaces of the pipeline are of good quality, simple operation, clean and hygienic, safe and reliable. Wire drawing of equipment support.

Optional membrane element model:
Microfiltration membrane elements: 0.05um, 0.1um, 0.2um, 0.3um, 0.45um
Ultrafiltration membrane elements: 1000D, 2000D, 3000D, 5000D, 8000D, 10KD, 20KD, 30KD, 50KD, 70KD, 100KD, 300KD, 500KD, 800KD
Nanofiltration membrane elements: 100D, 150D, 200D, 300D, 500D, 600D, 800D
Reverse osmosis membrane elements: RO1, RO2, RO3, RO4, RO5, RO6, RO7, SW30, BW30

Basic configuration:
One circulating pump, one booster pump, one jacketed circulating tank, one membrane shell, one membrane core, two flow meters, two pressure gauges, one temperature gauge, one heat exchanger, one basic electrical control cabinet Sets, two sets of frequency conversion control systems, equipment brackets, manual valves and several connecting pipes.

5. Nanofiltration membrane filtration system (BONA-GM-1818H)

Technical parameter:
Working pressure: 0-25bar
Working temperature: 4-55℃
Effective filtration area: ≥7m2
Total installed power: 4Kw
Power demand: three-phase/380V/50HZ/4Kw (recommended to reserve power supply according to the factory standard system)
Nanofiltration membrane core: roll structure, size: 2.5’×40’
Film core material: polyamide composite film
Membrane core withstand pH: 2-11
Equipment material: SS304
Equipment structure: integrated skid-mounted structure
Equipment size: 1350 (length) * 950 (width) * 1350 (height) mm
Cleaning water: demineralized water/purified water, recommendations: SiO2≤10ppm, Mn≤0.02ppm, Fe≤0.05ppm, pH=6-8, Ca hardness ≤50ppm
Cleaning cycle: cleaning at the end of each batch of production, membrane cleaning time <2 hours

Product features and process introduction:
1. The system is equipped with a multi-stage vertical centrifugal pump with a circulating pump, and the filter components are made of SS304; the booster pump is started by frequency conversion;
2. The system is manually controlled, pressure and temperature are displayed in real time, feedback and alarm protection;
3. The system is equipped with a heat exchanger, and the temperature of the material can be controlled through an external refrigerant;
4. The system uses three 2.5-inch membrane cores to ensure the smallest circulation volume to achieve high concentration of materials. This system is mainly used for the late concentration and desalination of the material liquid, and the circulation volume is small, which can effectively reduce the material volume and improve the final material concentration;
5. The main equipment is made of SS304 stainless steel except for the seals;
6. It adopts automatic argon filling protection, single-sided welding, double-sided forming, all welds are polished, smooth and flat, surface finish Ra<1.0µm, fillet welds, external butt welds and pipe ends are smoothly polished, and internal welds It is smoothly polished, the inner and outer surfaces of the pipeline are of good quality, simple operation, clean and hygienic, safe and reliable. Wire drawing of equipment support.

Optional membrane element model:
Microfiltration membrane elements: 0.05um, 0.1um, 0.2um, 0.3um, 0.45um
Ultrafiltration membrane elements: 1000D, 2000D, 3000D, 5000D, 8000D, 10KD, 20KD, 30KD, 50KD, 70KD, 100KD, 300KD, 500KD, 800KD
Nanofiltration membrane elements: 100D, 150D, 200D, 300D, 500D, 600D, 800D
Reverse osmosis membrane elements: RO1, RO2, RO3, RO4, RO5, RO6, RO7, SW30, BW30

Basic configuration:
One circulating pump, one booster pump, one circulating tank, three membrane shells, three membrane cores, one heat exchanger, two flow meters, two pressure gauges, one thermometer, one basic electrical control cabinet Sets, one set of frequency conversion control system, equipment brackets, manual valves and several connecting pipes.

Bona technical advantages:
1. Independently complete a number of domestic and foreign membrane equipment projects with rich experience;
2. Have a group of senior engineers in membrane engineering application with many years of technology development and engineering practice;
3. Professional technical support can be provided, and installation and debugging can be guided on site;
4. Perfect customer service system, regular return visits, equipment quality is guaranteed;
5. The company has a service center to provide you with fast, efficient and affordable instrument maintenance services.