Whatsapp: +86-18963064736

Wechat: +86-18963064736

QQ: 2862752579

TM: Bonabio

Address: Block D, Century Fortune Center, High-tech Zone, Jinan City, Shandong Province, China

Copyright(c)2020  ©  Shandong Bona Biological Technology Group Co., Ltd. 鲁ICP备12034225号-5








Separation and purification process development

Extraction, separation and purification process of rapamycin/sirolimus
Rapamycin (RAPA, trade name Sirolimus) is a new type of macrolide immunosuppressant with highly effective immunosuppressive effect. From the perspective of clinical application, rapamycin has a good anti-rejection effect, and has a good synergistic effect with immunosuppressants such as cyclosporine A (CsA) and tacrolimus (FK506), which is a curative effect A new type of immunosuppressant with good, low toxicity and no renal toxicity.
Paclitaxel Resin for extraction, separation and purification process of taxol
Paclitaxel (trade name Taxo1) is a unique anti-tumor natural drug in Taxus plants. It was first isolated in 1971 by American chemists Wani and Wallt, and was officially approved by the US FDA in 1992. New anti-ovarian cancer drug.
Chromatography packing for extraction, separation and purification of ascomycin (ascomycin, immunomycin, FK520)
Ascomycin (ascomycin, immunomycin, FK520) is a twenty-three carbon macrolide compound, an ethyl analog of the immunosuppressant tacrolimus (FK-506), and a synthetic pimecrolimus (Trade name Elidel) precursor material.
Organic acid separation and purification packing
Organic acids, such as citric acid, tartaric acid, malic acid, and ascorbic acid, are mostly combined with metal ions or combined with alkaloids to form salts. They are very effective active ingredients of Chinese herbal medicines.
Reverse chromatography medium for thymus method new separation and purification reverse chromatography packing reverse chromatography resin packing
Thymosin α1 (Thymosin) is a 28 peptide with strong acidity, with a molecular weight of 3108 and an isoelectric point of 4.2. The N-terminal is acetylated. The synthesized crude peptide contains many impurities with molecular size and properties similar to the product, which is not easy to purify.
Vancomycin extraction, separation and purification process
Vancomycin is a glycopeptide antibiotic isolated from the fermentation broth of a strain of Streptomycin orientalis by Micormick in 1956. It was approved by the US FDA in 1958 and was developed and marketed by Lilly.
Alkaloid separation and purification packing
Alkaloids are nitrogen-containing organic compounds derived from the plant kingdom. They are very effective active ingredients of Chinese herbal medicines. The effect on traditional silica gel or alumina chromatography is often not ideal.
Resin filler for separation and purification of daunorubicin, epirubicin, adriamycin, epirubicin, pirarubicin
For such products with similar structures, the SKP-20-4300 chromatography resin developed by Jinan Bona Biotechnology Co., Ltd. can solve the difficulty of separation and purification of the final product, and control the single impurity in the product below 0.1% without repeated crystallization.
Nemadectin (Nemadectin) Moxidectin (Moxidectin) extraction separation and purification chromatography packing SKP10N
Nemadectin (Nemadectin) is a 16-membered macrolide antibiotic, produced by Streptomyces cyaneogriseus sp. Noncyanogenus through fermentation process.
Chromatography packing for Huperzine extraction, separation and purification SKP-10-4100 SKR-10-4100
Huperzine A is a potent and reversible cholinesterase inhibitor, which is good for treating myasthenia gravis, improving memory decline in the elderly, and improving the memory and cognitive behavioral functions of Alzheimer's patients.
Page up