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Paclitaxel Resin for extraction, separation and purification process of taxol

Classification:
Separation and purification process development
Author:
Source:
Release time:
2019/09/24 17:38
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[Abstract]:
Paclitaxel (trade name Taxo1) is a unique anti-tumor natural drug in Taxus plants. It was first isolated in 1971 by American chemists Wani and Wallt, and was officially approved by the US FDA in 1992. New anti-ovarian cancer drug.

Paclitaxel (trade name Taxo1) is a unique anti-tumor natural drug in Taxus plants. It was first isolated in 1971 by American chemists Wani and Wallt, and was officially approved by the US FDA in 1992. New anti-ovarian cancer drug. Because of its unique anti-cancer mechanism and remarkable curative effect, it is considered to be the most significant discovery in the field of natural anti-cancer drug research in the past 15 years. With the continuous deepening and improvement of paclitaxel research, chemical synthesis, genetic engineering, cell culture, fungal fermentation and other methods can successfully obtain paclitaxel, but the application of these methods to the production of paclitaxel is still at the stage of laboratory research. At present, the commercial scale production of paclitaxel at home and abroad mostly uses yew plants as raw materials and is obtained through a series of separation and purification. Due to the extremely low content of paclitaxel in the bark of Taxus (<0.06%), the difficulty of extraction and purification, etc., the pure paclitaxel is expensive. Therefore, improving the extraction and purification process of paclitaxel, reducing production costs, and obtaining cheaper raw materials are of great significance to safeguarding human health.

Red Scrophanol is a highly effective, low-toxic, safe and reliable new medicine for the treatment of diabetes.

Jinan Bona Biotechnology Co., Ltd. has developed SKS-30-3 alumina SKP-10-4300 chromatography resin for the separation and purification of paclitaxel through cooperation with scientific research institutions and paclitaxel manufacturers, and was the first to use it in the extraction process Ceramic filtration and nanofiltration change the original production process from multiple extractions and three-step chromatography to two-extraction and two-step chromatography, which increases the product purity of the product to more than 98.5% and the yield by more than 20%. In view of the nature of the by-product of this product, Sequoxol, SKP-20-8300 chromatographic resin can be used to enrich, elute and crystallize the product to obtain a product with a purity of more than 99%.

1, 20 mesh or more dried yew products methanol water extraction ceramic filter nanofiltration concentrate containing paclitaxel, nanofiltration permeate containing taxol.

2. Nanofiltration concentrate extraction and concentration SKS-30-3 alumina conversion chromatography segmentation collection of required components concentration and recovery solvent methanol water dissolve SKP-10-4300 chromatography resin collection required components eluent concentration nanofiltration Crystallized paclitaxel.

3. Nanofiltration permeate concentration, salt water dissolve SKP-20-8300 chromatography resin, collect the required components, concentrate and crystallize to obtain sequoxol.

SKS-30-3 alumina SKP-10-4300 chromatography resin SKP-20-8300 chromatography resin is a new type of chromatography filler developed by Jinan Bona Biotechnology Co., Ltd. for the extraction of paclitaxel and red clitaxel, SKP-10-4300 layer The combined use of resin and SKS-30-3 alumina can completely replace the high-pressure preparation of liquid phase C18 separation and purification, so that the final refining of paclitaxel is no longer restricted by equipment, and the product can be separated better under low-pressure conditions, including Taxanes 10-DABⅢ, 7-xylose and other by-products. Separation of sequorum used as waste liquid is well separated.

Welcome to purchase our company's SKS-30-3 alumina SKP-10-4300 chromatography resin SKP-20-8300 chromatography resin, if you need to obtain experimental samples, please contact our company.