Chromatography packing for extraction, separation and purification of ascomycin (ascomycin, immunomycin, FK520)

Chromatography packing for extraction, separation and purification of ascomycin (ascomycin, immunomycin, FK520)

Ascomycin (ascomycin, immunomycin, FK520) is a twenty-three carbon macrolide compound, an ethyl analog of the immunosuppressant tacrolimus (FK-506), and a synthetic pimecrolimus (Trade name Elidel) precursor material. Since the launch of ascomycin and its derivatives, the market share has increased rapidly, and pimecrolimus has become the first clinical drug for transplant rejection after skin transplantation. Although great progress has been made in the fermentation and production of ascomycin, structural analogues appearing in the fermentation process have increased the difficulty of separation and purification of the substance.

Chromatography filler for separation and purification of ascomycin SKP-10-8300 SKL-30-4005