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Orlistat extraction, separation and purification preparation process

Classification:
Separation and purification process development
Author:
Source:
Release time:
2019/09/24 17:23
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[Abstract]:
Technical background: Orlistat is a safe obesity treatment drug, which can reduce the weight of patients, and can improve dyslipidemia and lower blood pressure. It was first marketed in the United States in 1998 and approved by the FDA in 2003 for obese adolescents aged 12-16.

Technical background: Orlistat is a safe obesity treatment drug, which can reduce the weight of patients, and can improve dyslipidemia and lower blood pressure. It was first marketed in the United States in 1998 and approved by the FDA in 2003 for obese adolescents aged 12-16.

The existing production methods include: 1. Full chemical synthesis, 2. Microbial fermentation to produce lipstatin lipstatin, and hydrogenation to synthesize orlistat.

Aiming at the complex extraction, separation and purification process of the original prastatin, the purification is difficult, it is difficult to obtain high-purity products, the reproducibility between batches is not good, and the fermentation unit has a greater impact on the downstream purification process of fermentation, Jinan Bona Biotechnology Co., Ltd. After a long period of research and development, SKS-10-200 silica gel and SKP-10-4500 chromatography resin for the separation and purification of lipstatin have been developed, and the original process has been improved, which greatly simplifies the production process and labor The strength is greatly reduced, the yield is higher, the production cost is lower, and the safety of the production process is higher.

Introduction to the extraction, separation and purification process of orlistat, lipstatin, and nibostatin: adding 5% diatomaceous earth/perlite plate and frame filter to the fermentation broth, alcohol extraction, concentration, microfiltration, heptane extraction, and acetonitrile degreasing silica gel Column (SKS-10-200 silica gel) acetone heptane elution SKP-10-4500 Chromatographic medium purity of lipstatin, nibostatin 95%, hydrogenation, concentration, SKP-10-4500 chromatography medium analysis The crystal purity is greater than 99%, the single impurity is less than 0.1%, and the total yield is 40%, reaching ICH standards.

If you want to buy our company's SKP-10-4500 chromatography resin, SKS-10-200 silica gel or request samples, please call our company. Our company will wholeheartedly provide you with technical support. Tel0531-88804339