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Extraction, separation and purification process of Shandong Bona Tripterygium A

Classification:
Separation and purification process development
Author:
Source:
Release time:
2019/08/21 17:18
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[Abstract]:
Triptolide, also known as triptolide, is a traditional Chinese medicine with a long history and wide application. Triptolide (Triptolide, TPL) is one of the main active ingredients of Triptolide, which has anti-inflammatory and immunosuppressive effects.

Triptolide, also known as triptolide, is a traditional Chinese medicine with a long history and wide application. Triptolide (Triptolide, TPL) is one of the main active ingredients of Triptolide, which has anti-inflammatory and immunosuppressive effects. Molecular formula: C20H24O6, molecular weight: 360.4, hardly soluble in water, easily soluble in methanol, dimethyl sulfoxide, absolute ethanol, ethyl acetate, chloroform, etc. In October 2012, researchers from the University of Minnesota found that a mouse model showed that triptolide is effective in the treatment of pancreatic cancer. The researchers then processed triptolide and finally obtained a water-soluble, injection-use new drug, minicin, which has excellent effects on killing tumor cells and shrinking tumors, which undoubtedly brings new hope to patients with pancreatic cancer .

A new method for extraction, separation and purification of triptolide

The authentic medicinal material Tripterygium wilfordii was crushed and sieved through 100 meshes, extracted with methanol/ethanol 3 times, concentrated under reduced pressure and evaporated to remove the solvent, acetonitrile brine phase extraction, concentration, chloroform extraction, concentration, SKS-30-200 alumina chromatography chloroform Methanol separation, SKS-10-4300 silica gel chromatography, the purity of triptolide is greater than 98%.

The SKP-10-450 chromatographic resin developed by Shandong Bona Biology can be used for the separation and purification of triptolide related derivatives, and the product purity reaches more than 99%.

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